Reza Erfanian Reza; Masoumeh Firouzi, PhD; Mohammad Hossein Nabian, MD; Masoud Darvishzadeh, PhD; Leila Oriadi Zanjani, MD; Shayan Abdollahzadegan; Reza Shahryar Kamrani, MD
Abstract
Background: The use of fibrin adhesive has broad background in medicine and peripheral nerve repair. The physical properties of these adhesives has restricted their usage. This experiment studied the performance and physical characteristics of fibrin glue (which is prepared from single donor human plasma) ...
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Background: The use of fibrin adhesive has broad background in medicine and peripheral nerve repair. The physical properties of these adhesives has restricted their usage. This experiment studied the performance and physical characteristics of fibrin glue (which is prepared from single donor human plasma) in the repair of posterior tibial nerve of rat.Methods: In this study, posterior tibial nerves of 40 rats were transected. In group A no repair was performed in group B repair was done by one microsuture in group C repair was done by three microsutures in group D by one suture plus fibrin adhesive and in group E repair was done just with fibrin adhesive. After 8 weeks of follow-up, Tibial Function Index and at the end of the study, adhesive strength inflammation and scar formation were measured.Results: Functional recovery in the eighth week for groups A and E were significantly lower than groups B and C (p < /em>=.03). No rat repaired with fibrin adhesive had dehiscence, while half of rats in group A had complete dehiscence- was significantly higher than the others groups (p < /em>=.002). Inflammation and scar tissue were similar between the groups.Conclusion: The produced fibrin adhesive provides required adhesive and could hold nerve stumps in long term.
